ISSN 0976-4550  
DOI: 10.21276/Ijabpt  
 
 
 
Peer Reviewed Online International Journal of Applied Biology and Pharmaceutical Technology www.ijabpt.com
 

ANTIPLASMODIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF ADENIA LOBATA, COLA GIGANTEA VAR. GLABRESCENS ANDENTADA MANNII, THREE TRADITIONAL PLANTS. Page No 12 to 15, Volume-9, Issue-1, Jan-Mar-2018

Kipré Gueyraud Rolland, Offoumou Rostand M’Baï, Silué Kigbafori Dieudonné, Bouablé Guy Martial, Zirihi Guédé Noel, Djaman Allico Joseph

Medicinal plants are currently being evaluated as source of promisingantimalarial agents.

Plant extracts contain phytochemical constituents for miscellaneous medicinal activities which are bioactive in nature. There is growing interest in the use of plants for the treatment and prevention of malaria.

In this study, we have evaluated the claimed antimalarial properties of six extracts from three plants utilized in traditional malaria remediesand we have investigated phytochemical screening.

Schizontocidal activity was measured using a standard in vitro assay, with NF54 and K1 Plasmodium falciparum strains. From the 6 extracts tested, only aqueous extract of Entada manniishowed a promising activity (5 ≤ IC50≤ 15 µg/mL) on resistant strain K1. All extracts contained saponins, polyterpenes and sterols.

Key words: Traditional medicine; Medicinal plants; Malaria; Antimalarial; Plasmodium falciparum.

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