ISSN 0976-4550  
DOI: 10.21276/Ijabpt  
 
 
 
Peer Reviewed Online International Journal of Applied Biology and Pharmaceutical Technology www.ijabpt.com
 

EVALUATION OF ANTI-DIABETIC EFFICACY OF MANGOPULP IN STREPTOZOTOCIN INDUCED DIABETIC RATS  Page No 79 to 83, Volume-8, Issue-3, July-Sept-2017

Subrahmanyam G, Veeranjaneyulu C, Himakar Reddy K, Pasupuleti Sreenivasa Rao, and Ramalingam K

Background: Diabetes mellitus is a most common endocrine disorder acquiring 4-5% of the world population, characterized by hyperglycemia, hypoinsulinaemia or insulin resistance, leading to increased morbidity and mortality. Though several anti-diabetic drugs are available in the market some have adverse side effects. Mangifera indica have been used in traditional medicine and possess anti-diabetic, hypoglycemic, hypolipidemic and hypertension.

Objective: The present study was taken up to evaluate the anti-diabetic activity of mango pulp in streptozotocin (STZ) induced diabetic rats.

Method: Male wistar albino rats were divided in to four groups. 5g/kg/day of mango pulp was orally administered for 8 weeks  to see the efficacy of anti-diabetic activity of mango pulp in  STZ induced rats and non- diabetic rats.

Results: Glucose, lipid profile, insulin resistance, AST and ALT biochemical parameters were analyzed after administration of mango pulp at 5g/kg/day in all the experimental groups. From the results data it is shown that mango pulp possess anti-diabetic activity.

Key words: Mangifera indica, mango pulp, diabetes, insulin resistance

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