ISSN 0976-4550  
DOI: 10.21276/Ijabpt  
 
 
 
Peer Reviewed Online International Journal of Applied Biology and Pharmaceutical Technology www.ijabpt.com
 

ANTIPYRETIC ACTIVITY OF EUPATORIUM ADENOPHORUM LEAVES. Page No 1 to 4, Volume-8, Issue-3, July-Sept-2017  

CL. Ringmichon and Bindu Gopalkrishnan

In present investigation, the leaf of Eupatorium adenophorum Spreng. of family Asteraceae is tested for antipyretic activity. The decoction of the said leaves is been used by the Naga tribe in curing fever since ancient times. To prove its claim scientifically the present study was done.  The effect of aqueous extracts of leaves was tested on yeast induced pyrexia in albino rats. Prior to the study, acute oral toxicity testing of drug was performed as per OECD guidelines. The drug dosage of 300, 400 and 500 mg/Kg body weight was tried on the fever induced rats. It was compared with the standard drug Paracetamol (150 mg/Kg body wt) fed rats. The aqueous extract of leaves showed significant antipyretic activity after 2 hours in the dosage of 300, 400 and 500 mg/Kg body wt as that of compared standard drug paracetamol. Thus preclinical crude drug of Eupatorium adenophorum was proved to be effective antipyretic agent as claimed by the Nagas.

Key words: Eupatorium adenophorum, leaves, antipyretic, paracetamol

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