ISSN 0976-4550  
DOI: 10.21276/Ijabpt  
 
 
 
Peer Reviewed Online International Journal of Applied Biology and Pharmaceutical Technology www.ijabpt.com
 

HEPATOPROTECTIVE ACTIVITY OF ETHANOL EXTRACT OF BACOLEPIS NERVOSA AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS  Page No 63 to 72, Volume-8, Issue-3, July-Sept-2017

A. Arockia Jenecius Alphonse

Medicinal plants have a long standing history in many indigenous communities and continue to provide useful tools for treating various diseases. Our aim was to evaluate the hepatoprotective effect of ethanol extract of Bacolepis nervosa stem and leaves with a view to explore its use for the treatment of hepatotoxicity in human. Oral administration of ethanol extract of B. nervosa (150 and 300 mg/kg) effectively inhibited CCl4 induced changes in the serum marker enzymes, cholesterol, serum protein and bilirubin in a dose dependent manner as compared to the normal and the standard drug silymarin treated groups. Hepatic steatosis, fatty infiltration, hydropic degeneration and necrosis observed in CCl4 treated groups which were completely absent in histology of the liver sections of the animals treated with the extracts. The results suggest that the ethanol extracts of stem and leaves of B. nervosa possess significant potential as hepatoprotective agent.

Key words: Ethanol, Carbon tetrachloride, Hepatotoxicity, Albino rats

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