ISSN 0976-4550  
DOI: 10.21276/Ijabpt  
 
 
 
Peer Reviewed Online International Journal of Applied Biology and Pharmaceutical Technology www.ijabpt.com
 

ALUMINUM AND FLUORIDE IMPACTS CORTEX, HIPPOCAMPUS AND DENTATE GYRUS STRUCTURE IN RATS: PROTECTIVE ROLE OF RESVERATROL.  Page No 89 to 97, Volume-8, Issue-1, Jan-Mar-2017   DOI: 10.21276/ijabpt.2017.8.1.13

C S Reddy Nallagouni and K. Pratap Reddy

ABSTRACT: Metals such as aluminum and Fluoride have been implicated in the etiology of several neurodegenerative disorders. Resveratrol, a natural polyphenol, exerting a wide range of biological and pharmacological activities including its antioxidative properties against neurodegenerative disorders through its ability to lessen oxidative stress. Rats were divided into 4 groups. Group –I was served as control. Group –II was intoxicated with Alcl3 (100 mg/kg b.w) along with Sodium fluoride (10 mg/kg b.w). Group –III was administered with Alcl3 (100 mg/kg b.w) + Sodium fluoride (10 mg/kg b.w) + resveretrol (30 mg/kg b.w).  Group–IV was administered with resveretrol (30 mg/kg b.w) alone for 8 weeks. The obtained results showed significant oxidative stress induced neuronal damage in cerebral cortex and hippocampus in intoxicated rats where as significant reduction in neuronal damage in the rats administered with resveratrol against aluminium along with fluoride when observed with certain stains. Hence, the results of the present study reveal that the resveratrol has potential neuroprotective properties to diminish the oxidative stress on Cortical and Hippocampal neuronal loss and cognitive impairment by aluminum and fluoride intoxication.

Key words: Aluminium, Fluoride, Resveratrol, cortex, Hippocampus

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